Yun Zhang and William M. Pardridge Barrier Drug Targeting System Administration of Brain-Derived Neurotrophic Factor Conjugated to a Blood-Brain Neuroprotection in Transient Focal Brain Ischemia After Delayed Intravenous
نویسنده
چکیده
Barrier Drug Targeting System Administration of Brain-Derived Neurotrophic Factor Conjugated to a Blood-Brain Neuroprotection in Transient Focal Brain Ischemia After Delayed Intravenous Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.32.6.1378 2001;32:1378-1384 Stroke. http://stroke.ahajournals.org/content/32/6/1378 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system.
BACKGROUND AND PURPOSE Neuroprotection with brain-derived neurotrophic factor (BDNF) requires direct injection into the brain owing to poor transport of the neurotrophin through the blood-brain barrier (BBB) in vivo. The present studies investigate whether BDNF alone or conjugated to a BBB drug targeting system is neuroprotective in focal, reversible brain ischemia after delayed intravenous adm...
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